Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological and anatomical relevance. We find that heart organoids produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts. We also show that they recapitulate several aspects of cardiac development, including large atrial and ventricular chambers, proepicardial organ formation, and retinoic acid-mediated anterior-posterior patterning, mimicking the developmental processes found in the post-heart tube stage primitive heart
HALO: A Unified Vision-Language-Action Model for Embodied Multimodal Chain-of-Thought Reasoning
This paper presents a scalable and reproducible protocol for generating human heart organoids (hHOs) from pluripotent stem cells using a three-step Wnt signaling modulation strategy. These organoids self-organize into complex structures that replicate key aspects of the developing human heart, including chamber formation, vascular networks, and multiple cardiac cell lineages, providing a high-throughput platform for disease modeling and drug testing.
A key challenge in benchmarking AI system security – one we highlighted in our blog post, and emphasized by other top security researchers – is the need for security evaluations to constantly evolve and adapt in order to assess the risks from real-world adversaries, who continuously seek out new attacks and tailor their techniques to particular targets and defenses.
TxPert, a latent-transfer-based deep learning method that uses multiple knowledge graphs of gene (product)–gene (product) relationships to predict transcriptomic perturbation effects.
Human neural crest heart assembloids resembling the major directions of neural crest differentiation in the human embryonic heart, including parasympathetic innervation and the mesenchymal component of the outflow tract, provide a human-relevant embryonic platform for studying congenital heart defects and drug safety.