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Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological and anatomical relevance. We find that heart organoids produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts. We also show that they recapitulate several aspects of cardiac development, including large atrial and ventricular chambers, proepicardial organ formation, and retinoic acid-mediated anterior-posterior patterning, mimicking the developmental processes found in the post-heart tube stage primitive heart

HALO: A Unified Vision-Language-Action Model for Embodied Multimodal Chain-of-Thought Reasoning

The authors introduce ChatEHR, an internally developed, vendor-agnostic system for integrating large language models (LLMs) directly into clinical workflows within an academic medical center's electronic health record. By enabling real-time access to longitudinal patient data through both automated tasks and an interactive chat interface, the platform successfully reduces manual documentation burden and facilitates decision-making. The authors also establish a robust framework for governance, continuous performance monitoring, and value assessment, demonstrating a replicable model for other health systems.

This paper proposes the development of an AI-Driven Digital Organism (AIDO), a comprehensive, multiscale foundation model system designed to simulate biological systems from the molecular level to entire organisms. By integrating multimodal datasets and hierarchical deep learning architectures, AIDO aims to provide a safe, scalable, and programmable environment for biomedical research and drug discovery. The framework establishes a unified blueprint for modeling complex biological networks, bridging gaps between genotype, phenotype, and environmental influences.

quantum-classical supercomputing: quantum chemistry of protein-ligand complexes

Researchers developed a novel stem cell-based protocol to generate 'cardiobots'—self-organizing aggregates capable of muscle-powered motility. By optimizing mesoderm and cardiogenic induction through precise growth factor signaling and synthetic organizers, the team successfully engineered bio-aggregates with enhanced contractile areas and increased motility compared to existing gastruloid models. This approach provides a new framework for creating autonomous, muscle-propelled biological machines and exploring the evolutionary origins of movement in early multicellular organisms.